Recombinant Human HGFA Inhibitor 2 protein (denatured) (ab137166)

Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMADRER SIHDFCLVSK VVGRCRASMP RWWYNVTDGS CQLFVYGGCD GNSNNYLTKE ECLKKCATVT ENATGDLATS RNAADSSVPS APRRQDSEDH SSDMFNYEEY CTANAVTGPC RASFPRWYFD VERNSCNNFI YGGCRGNKNS YRSEEACMLR CFRQQENPPL PLGSK
    • Molecular weight

      22 kDa including tags
    • Amino acids

      28 to 197
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab137166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    > 85 % SDS-PAGE.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • AL024025
    • Bikunin, placental
    • C76321
    • DIAR3
    • FLJ45571
    • HAI-2
    • HAI2
    • Hepatocyte growth factor activator inhibitor type 2
    • Kop
    • Kunitz type protease inhibitor 2
    • Kunitz-type protease inhibitor 2
    • Kunitz-type serine protease inhibitor
    • MGC72638
    • PB
    • Placental bikunin
    • Serine peptidase inhibitor Kunitz type 2
    • Serine protease inhibitor, Kunitz type, 2
    • SPINT2
    • SPIT2_HUMAN
    see all
  • Function

    Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
  • Tissue specificity

    Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
  • Involvement in disease

    Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3) [MIM:270420]; also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes.
  • Sequence similarities

    Contains 2 BPTI/Kunitz inhibitor domains.
  • Domain

    This inhibitor contains two inhibitory domains.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab137166 (3µg)

References

ab137166 has not yet been referenced specifically in any publications.

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