Description

  • Product name

    Recombinant Human HIF1AN/FIH-1 protein
  • Purity

    > 90 % SDS-PAGE.
    ab86916 was purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN

Specifications

Our Abpromise guarantee covers the use of ab86916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Previously labelled as HIF1AN.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituent: 0.316% Tris HCl

General Info

  • Alternative names

    • DKFZp762F1811
    • Factor inhibiting HIF-1
    • Factor inhibiting HIF1
    • FIH 1
    • FIH-1
    • FIH1
    • FLJ20615
    • FLJ22027
    • HIF1AN
    • HIF1N_HUMAN
    • Hypoxia inducible factor 1 alpha inhibitor
    • Hypoxia inducible factor 1 alpha subunit inhibitor
    • Hypoxia inducible factor asparagine hydroxylase
    • Hypoxia-inducible factor 1-alpha inhibitor
    • Hypoxia-inducible factor asparagine hydroxylase
    • Peptide aspartate beta dioxygenase
    see all
  • Function

    Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.
  • Sequence similarities

    Contains 1 JmjC domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of 3µg ab86916

References

ab86916 has not yet been referenced specifically in any publications.

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