Description

  • Product name

    Recombinant human HIPK1 protein
    See all HIPK1 proteins and peptides
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Amino acids

      156 to 555

Associated products

Specifications

Our Abpromise guarantee covers the use of ab60867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • Form

    Liquid
  • Additional notes

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.0038% EGTA, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol, 0.87% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names

    • Hipk 1
    • Hipk1
    • HIPK1_HUMAN
    • Homeodomain interacting protein kinase 1
    • Homeodomain interacting protein kinase 1 like protein
    • Homeodomain-interacting protein kinase 1
    • Myak
    • Nbak 2
    • Nbak2
    • Nuclear body associated kinase 2
    • Nuclear body associated kinase 2b
    see all
  • Function

    May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.
  • Tissue specificity

    Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated. Phosphorylated and activated by JNK1.
  • Cellular localization

    Nucleus. Cytoplasm. Predominantly nuclear.
  • Information by UniProt

Images

  • The specific activity of HIPK1 (ab60867) was determined to be 79 nmol/min/mg as per activity assay protocol
  • SDS PAGE analysis of ab60867
  • SDS PAGE analysis of ab60867
  • Sample Kinase Activity Plot.
  • ab60867 on SDS-PAGE, MW ~71 kDa.

References

ab60867 has not yet been referenced specifically in any publications.

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