Recombinant Human Histamine H2 Receptor co-expressed with GsaS protein (ab90408)

Description

  • Product name

    Recombinant Human Histamine H2 Receptor co-expressed with GsaS protein
  • Expression system

    Baculovirus infected Sf9 cells
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      78 kDa including tags
    • Tags

      His tag C-Terminus , DDDDK tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab90408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.40
    Constituents: 0.11875% Magnesium chloride, 1.185% Tris HCl, 0.0292% EDTA

General Info

  • Alternative names

    • Adenylate cyclase stimulating G alpha protein
    • AHO
    • C20orf45
    • GNAS
    • GNAS complex locus
    • GNAS1
    • GPSA
    • Gs alpha subunit
    • GSA
    • GSP
    • Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein alpha stimulating activity polypeptide 1
    • Guanine nucleotide binding protein G(s) subunit alpha isoforms short
    • Guanine nucleotide regulatory protein
    • H2R
    • Histamine H2 receptor
    • Histamine receptor H2
    • Neuroendocrine secretory protein
    • PHP1A
    • PHP1B
    see all
  • Relevance

    The H2 subclass of histamine receptors mediates gastric acid secretion. It also appears to regulate gastrointestinal motility and intestinal secretion. HRH2 has a possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined.
  • Cellular localization

    Histamine H2 Receptor: Membrane; multi pass membrane protein.

References

ab90408 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for contacting Abcam about ab90408.

The product ab90408 is a fusion protein and it has a molecular weight of 33 + 45 = 78kDa.

Please let me know if there is anything else I can help you with.

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