Product nameRecombinant Human Histone acetyltransferase MYST3 / MOZ protein
See all Histone acetyltransferase MYST3 / MOZ proteins and peptides
Protein lengthProtein fragment
Amino Acid Sequence
Amino acids81 to 179
Tagsproprietary tag N-Terminus
Our Abpromise guarantee covers the use of ab159926 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
Previously labelled as Histone acetyltransferase MYST3.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.31% Glutathione, 0.79% Tris HCl
- HAT 3
- Histone acetyltransferase MYST3
- Monocytic leukemia zinc finger protein
FunctionHistone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
Involvement in diseaseNote=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
Sequence similaritiesBelongs to the MYST (SAS/MOZ) family.
Contains 1 C2HC-type zinc finger.
Contains 1 H15 (linker histone H1/H5 globular) domain.
Contains 2 PHD-type zinc fingers.
DomainThe N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
- Information by UniProt
ab159926 has not yet been referenced specifically in any publications.