The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 µg/µl.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
High mobility group (nonhistone chromosomal) protein isoform I C
High mobility group (nonhistone chromosomal) protein isoform IC
High Mobility Group AT hook 2
High Mobility Group AT hook protein 2
High mobility group AT-hook protein 2
High mobility group protein HMGI C
High mobility group protein HMGI-C
High mobility group protein HMGIC
High mobility group protein I, isoform C
Non histone chromosomal architectural protein HMGI C
Non histone chromosomal architectural protein HMGIC
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
Involvement in disease
Note=A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas. Note=A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas. Note=A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma. Note=A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.
Belongs to the HMGA family. Contains 3 A.T hook DNA-binding domains.
Expressed predominantly during embryogenesis.
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.