Recombinant Human HMGCR protein (ab132810)

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Description

  • Product name

    Recombinant Human HMGCR protein
    See all HMGCR proteins and peptides

  • Expression system

    Wheat germ

  • Accession

    P04035-2

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYEC PKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTI FSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQ DEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMS VLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPN PVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSL KNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVI KPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQ ILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLS KKLSEPSSLQYLPYRDYNYSLLGGGASSRVLADGMTRGPVVRLPRACDSA EVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRG KSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHA ANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIG TVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSL MAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA

    • Predicted molecular weight

      118 kDa including tags

    • Amino acids

      1 to 835

Specifications

Our Abpromise guarantee covers the use of ab132810 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid

  • Additional notes

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • 3 hydroxy 3 methylglutaryl CoA reductase
    • 3 hydroxy 3 methylglutaryl Coenzyme A reductase
    • 3 hydroxymethylglutaryl CoA reductase
    • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
    • 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • 3H3M
    • HMDH_HUMAN
    • HMG CoA reductase
    • HMG CoAR
    • HMG-CoA reductase
    • Hmgcr
    • Hydroxymethylglutaryl CoA reductase
    • LDLCQ3
    • MGC103269
    • Red
    see all

  • Function

    This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.

  • Pathway

    Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

  • Sequence similarities

    Belongs to the HMG-CoA reductase family.

  • Cellular localization

    Endoplasmic reticulum membrane. Peroxisome membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human HMGCR protein (ab132810)
    SDS-PAGE - Recombinant Human HMGCR protein (ab132810)
    12.5% SDS-PAGE analysis of ab132810 stained with Coomassie Blue.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab132810? Please let us know so that we can cite the reference in this datasheet.

ab132810 has not yet been referenced specifically in any publications.

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