Description

  • Product name

    Recombinant Human HMGN3 protein
  • Purity

    > 95 % SDS-PAGE.
    ab183234 was purified using conventional chromatography.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTS AKKEPGAKIS RGAKGKKEEK QEAGKEGTEN
    • Predicted molecular weight

      11 kDa including tags
    • Amino acids

      1 to 77
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NP_620058

Specifications

Our Abpromise guarantee covers the use of ab183234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names

    • DKFZp686E20226
    • FLJ42187
    • High mobility group nucleosomal binding domain 3
    • High mobility group nucleosome-binding domain-containing protein 3
    • HMGN3
    • HMGN3_HUMAN
    • OTTHUMP00000016772
    • OTTHUMP00000016773
    • PNAS 24
    • PNAS 25
    • PNAS24
    • PNAS25
    • Thyroid hormone receptor interacting protein 7
    • Thyroid receptor-interacting protein 7
    • TR-interacting protein 7
    • TRIP 7
    • TRIP-7
    • TRIP7
    see all
  • Function

    Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
  • Tissue specificity

    Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
  • Sequence similarities

    Belongs to the HMGN family.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab183234 (3µg)

References

ab183234 has not yet been referenced specifically in any publications.

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