Description

  • Product name

    Recombinant Human hnRNP A1 protein
  • Purity

    > 90 % SDS-PAGE.
    ab123212 was purified using conventional chromatography and is > 90% pure by SDS - PAGE.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSKSESP KEPEQLRKLF IGGLSFETTD ESLRSHFEQW GTLTDCVVMR DPNTKRSRGF GFVTYATVEE VDAAMNARPH KVDGRVVEPK RAVSREDSQR PGAHLTVKKI FVGGIKEDTE EHHLRDYFEQ YGKIEVIEIM TDRGSGKKRG FAFVTFDDHD SVDKIVIQKY HTVNGHNCEV RKALSKQEMA SASSSQRGRS GSGNFGGGRG GGFGGNDNFG RGGNFSGRGG FGGSRGGGGY GGSGDGYNGF GNDGSNFGGG GSYNDFGNYN NQSSNFGPMK GGNFGGRSSG PYGGGGQYFA KPRNQGGYGG SSSSSSYGSG RRF
    • Predicted molecular weight

      37 kDa including tags
    • Amino acids

      1 to 320
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab123212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry

    MALDI-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 40% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • HNRNPA 1
    • Helix destabilizing protein
    • Helix-destabilizing protein
    • Heterogeneous nuclear ribonucleoprotein A1
    • Heterogeneous nuclear ribonucleoprotein A1B protein
    • Heterogeneous nuclear ribonucleoprotein B2 protein
    • Heterogeneous nuclear ribonucleoprotein core protein A1
    • hnRNP A1
    • hnRNP core protein A1
    • HNRNPA1
    • HNRPA1
    • MGC102835
    • Nuclear ribonucleoprotein particle A1 protein
    • ROA1_HUMAN
    • Single strand DNA binding protein UP1
    • Single strand RNA binding protein
    • Single-strand RNA-binding protein
    see all
  • Function

    Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
  • Sequence similarities

    Contains 2 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications

    Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.
    Sumoylated.
  • Cellular localization

    Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab123212 (3 µg)

References

ab123212 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Answer

Thank you for contacting us.

Regrettably, the biological activity of this product has not yet been tested. Although it is scheduled to be tested eventually, we can’t give you a specific date on when we will have the results.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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