Recombinant Human hnRNP A2B1 protein (ab224866)
Key features and details
- Expression system: Escherichia coli
- Purity: > 90% SDS-PAGE
- Tags: GST tag N-Terminus
- Suitable for: SDS-PAGE
Description
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Product name
Recombinant Human hnRNP A2B1 protein
See all hnRNP A2B1 proteins and peptides -
Purity
> 90 % SDS-PAGE. -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSR GFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVK KLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDD HDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEDLEVAILEVAPVMEEEE EDMVVEDLDMATRVGATEVVMTTMEEEIMEVEITMILEIITSNLLTTVQ -
Predicted molecular weight
55 kDa including tags -
Amino acids
1 to 249 -
Tags
GST tag N-Terminus -
Additional sequence information
(BC000506).
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab224866 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.2
Constituents: 50% Glycerol (glycerin, glycerine), Tris buffer
General Info
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Alternative names
- Heterogeneous nuclear ribonucleoprotein A2
- Heterogeneous nuclear ribonucleoprotein A2/B1
- Heterogeneous nuclear ribonucleoprotein B1
see all -
Function
Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous. -
Sequence similarities
Contains 2 RRM (RNA recognition motif) domains. -
Cellular localization
Nucleus > nucleoplasm. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus. - Information by UniProt
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab224866 has been referenced in 3 publications.
- Frederiksen SB et al. Identification of SRSF10 as a regulator of SMN2 ISS-N1. Hum Mutat 42:246-260 (2021). PubMed: 33300159
- Grønning AGB et al. DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning. Nucleic Acids Res 48:7099-7118 (2020). PubMed: 32558887
- Bruun GH et al. Blocking of an intronic splicing silencer completely rescues IKBKAP exon 20 splicing in familial dysautonomia patient cells. Nucleic Acids Res 46:7938-7952 (2018). PubMed: 29762696