Recombinant Human HP1BP3 protein (ab162358)

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Description

  • Product name

    Recombinant Human HP1BP3 protein

  • Expression system

    Wheat germ

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRE TPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEP ENEEKEENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQ TPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRG YLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSA VDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQL LKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAI AAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQI SGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEE PPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPP KAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFR VKK

    • Amino acids

      1 to 553

    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid

  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Heterochromatin protein 1, binding protein 3
    • Heterochromatin protein 1-binding protein 3
    • HP1 BP74
    • HP1B3_HUMAN
    • HP1BP 3
    • HP1BP3
    • MGC28927
    • MGC43701
    • MGC72624
    • OTTHUMP00000002717
    • OTTHUMP00000002719
    • OTTHUMP00000002720
    • Protein HP1 BP74
    • Protein HP1-BP74
    • RP5 930J4.3
    see all

  • Function

    Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).

  • Sequence similarities

    Contains 3 H15 (linker histone H1/H5 globular) domains.

  • Domain

    A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.

  • Cellular localization

    Nucleus. Chromosome. localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human HP1BP3 protein (ab162358)
    SDS-PAGE - Recombinant Human HP1BP3 protein (ab162358)
    ab162358 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162358 has not yet been referenced specifically in any publications.

Publishing research using ab162358? Please let us know so that we can cite the reference in this datasheet.

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