Recombinant Human HP1BP3 protein (ab162358)

Our Abpromise guarantee covers the use of ab162358 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Alternative names
- Heterochromatin protein 1, binding protein 3
- Heterochromatin protein 1-binding protein 3
- HP1 BP74
- HP1B3_HUMAN
- HP1BP 3
- HP1BP3
- MGC28927
- MGC43701
- MGC72624
- OTTHUMP00000002717
- OTTHUMP00000002719
- OTTHUMP00000002720
- Protein HP1 BP74
- Protein HP1-BP74
- RP5 930J4.3
see all
Function

Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Sequence similarities

Contains 3 H15 (linker histone H1/H5 globular) domains.
Domain

A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
Cellular localization

Nucleus. Chromosome. localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
Target information above from: UniProt accession Q5SSJ5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human HP1BP3 protein (ab162358)

ab162358 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ab162358 has not yet been referenced specifically in any publications.

Publishing research using ab162358? Please let us know so that we can cite the reference in this datasheet.

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