Recombinant Human HP1BP3 protein (ab162358)
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Description
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Product name
Recombinant Human HP1BP3 protein -
Expression system
Wheat germ -
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MATDTSQGELVHPKALPLIVGAQLIHADKLGEKVEDSTMPIRRTVNSTRE TPPKSKLAEGEEEKPEPDISSEESVSTVEEQENETPPATSSEAEQPKGEP ENEEKEENKSSEETKKDEKDQSKEKEKKVKKTIPSWATLSASQLARAQKQ TPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRG YLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSA VDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQL LKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAI AAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQI SGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEE PPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPP KAKTPAKKTRPSSTVIKKPSGGSSKKPATSARKEVKLPGKGKSTMKKSFR VKK -
Amino acids
1 to 553 -
Tags
GST tag N-Terminus
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Specifications
Our Abpromise guarantee covers the use of ab162358 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
Western blot
ELISA
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Form
Liquid -
Additional notes
Protein concentration is above or equal to 0.05 mg/ml. -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.31% Glutathione, 0.79% Tris HCl
General Info
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Alternative names
- Heterochromatin protein 1, binding protein 3
- Heterochromatin protein 1-binding protein 3
- HP1 BP74
see all -
Function
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). -
Sequence similarities
Contains 3 H15 (linker histone H1/H5 globular) domains. -
Domain
A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA. -
Cellular localization
Nucleus. Chromosome. localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S). - Information by UniProt
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Datasheets and documents
References
ab162358 has not yet been referenced specifically in any publications.