Description

  • Product name

    Recombinant human HRG beta 1 protein
    See all HRG beta 1 proteins and peptides
  • Biological activity

    The activity of HRG beta 1 is determined by the ability to stimulate proliferation of MC7 cells under serum free conditions and is typically less than 0.3 ng/mL.

  • Purity

    > 95 % SDS-PAGE.
    The purity of ab187226 is determined by reducing and non-reducing SDS-PAGE.
  • Endotoxin level

    <=1.000 Eu/µg
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MSHLVKCAEK EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAE
    • Predicted molecular weight

      8 kDa
    • Amino acids

      177 to 241

Specifications

Our Abpromise guarantee covers the use of ab187226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C long term. For long term storage it is recommended to add a carrier protein on reconstitution (0.1% HSA or BSA).

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.

General Info

  • Alternative names

    • Acetylcholine receptor inducing activity
    • ARIA
    • Breast cancer cell differentiation factor p45
    • GGF
    • GGF2
    • glial growth factor
    • Heregulin
    • Heregulin beta1
    • heregulin, alpha (45kD, ERBB2 p185 activator)
    • HGL
    • HRG
    • HRG beta 1A
    • HRG1
    • HRGA
    • NDF
    • neu differentiation factor
    • Neuregulin 1
    • NRG1
    • sensory and motor neuron derived factor
    • SMDF
    see all
  • Relevance

    HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).
  • Cellular localization

    Secreted

Images

  •  SDS PAGE analysis of ab187226 under non-reducing (-) and reducing (+) conditions. Stained with Coomassie Blue.

References

ab187226 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab187226.
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