The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
17 @beta HSD III
17 beta HSD 3
17-@beta hydroxysteroid dehydrogenase III
17-beta-hydroxysteroid dehydrogenase type 3
Estradiol 17 beta dehydrogenase
Estradiol 17 beta dehydrogenase 3
Hydroxysteroid (17 beta) dehydrogenase 3
Short chain dehydrogenase/reductase family 12C member 2
Testicular 17 @beta hydroxysteroid dehydrogenase III
Testicular 17 beta hydroxysteroid dehydrogenase
Testicular 17-beta-hydroxysteroid dehydrogenase
Testosterone 17 beta dehydrogenase 3
Testosterone 17-beta-dehydrogenase 3
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
Hormone biosynthesis; testosterone biosynthesis.
Involvement in disease
Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH) [MIM:264300]. These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place.
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.