Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLD ARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEH VGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP LVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVK ISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIM KEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS LADYILTRSWPKPAQAV
    • Amino acids

      1 to 317
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab152898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • 17-beta-HSD 6
    • 17-beta-HSD6
    • 17-beta-hydroxysteroid dehydrogenase type 6
    • 3 hydroxysteroid epimerase
    • 3(alpha >beta) hydroxysteroid epimerase
    • 3(alpha >beta) hydroxysteroid epimerasel
    • 3-alpha->beta-HSE
    • 3-alpha->beta-hydroxysteroid epimerase
    • H17B6_HUMAN
    • HSD17B6
    • HSE
    • Hydroxysteroid (17 beta) dehydrogenase 6
    • Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse)
    • Hydroxysteroid 17 beta dehydrogenase 6
    • NAD+ dependent 3 alpha hydroxysteroid dehydrogenase
    • NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase
    • Oxidative 3 alpha hydroxysteroid dehydrogenase
    • Oxidative 3-alpha hydroxysteroid dehydrogenase
    • Oxidoreductase
    • Retinol dehydrogenase
    • RODH
    • SDR9C6
    • Short chain dehydrogenase/reductase family 9C, member 6
    see all
  • Function

    NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
  • Tissue specificity

    Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.
  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization

    Microsome membrane. Early endosome membrane.
  • Information by UniProt

Images

  • ab152898 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab152898 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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