Recombinant Human Hsp105/HSP110 protein (ab78790)

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SDS-PAGE - Recombinant Human Hsp105/HSP110 protein (ab78790)

    Key features and details

    • Expression system: Escherichia coli
    • Purity: > 90% SDS-PAGE
    • Suitable for: SDS-PAGE

    Description

    • Product name

      Recombinant Human Hsp105/HSP110 protein

    • Purity

      > 90 % SDS-PAGE.
      ab78790 is purified using conventional chromatography techniques.

    • Expression system

      Escherichia coli

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Sequence

        MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSVV GLDVGSQSCY IAVARAGGIE TIANEFSDRC TPSVISFGSK NRTIGVAAKN QQITHANNTV SNFKRFHGRA FNDPFIQKEK ENLSYDLVPL KNGGVGIKVM YMGEEHLFSV EQITAMLLTK LKETAENSLK KPVTDCVISV PSFFTDAERR SVLDAAQIVG LNCLRLMNDM TAVALNYGIY KQDLPSLDEK PRIVVFVDMG HSAFQVSACA FNKGKLKVLG TAFDPFLGGK NFDEKLVEHF CAEFKTKYKL DAKSKIRALL RLYQECEKLK KLMSSNSTDL PLNIECFMND KDVSGKMNRS QFEELCAELL QKIEVPLYSL LEQTHLKVED VSAVEIVGGA TRIPAVKERI AKFFGKDIST TLNADEAVAR GCALQCAILS PAFKVREFSV TDAVPFPISL IWNHDSEDTE GVHEVFSRNH AAPFSKVLTF LRRGPFELEA FYSDPQGVPY PEAKIGRFVV QNVSAQKDGE KSRVKVKVRV NTHGIFTIST ASMVEKVPTE ENEMSSEADM ECLNQRPPEN PDTDKNVQQD NSEAGTQPQV QTDAQQTSQS PPSPELTSEE NKIPDADKAN EKKVDQPPEA KKPKIKVVNV ELPIEANLVW QLGKDLLNMY IETEGKMIMQ DKLEKERNDA KNAVEEYVYE FRDKLCGPYE KFICEQDHQN FLRLLTETED WLYEEGEDQA KQAYVDKLEE LMKIGTPVKV RFQEAEERPK MFEELGQRLQ HYAKIAADFR NKDEKYNHID ESEMKKVEKS VNEVMEWMNN VMNAQAKKSL DQDPVVRAQE IKTKIKELNN TCEPVVTQPK PKIESPKLER TPNGPNIDKK EEDLEDKNNF GAEPPHQNGE CYPNEKNSVN MDLD

    Specifications

    Our Abpromise guarantee covers the use of ab78790 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Liquid

    • Additional notes

       This product was previously labelled as Hsp105

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.242% Tris, 0.29% Sodium chloride

    General Info

    • Alternative names

      • Antigen NY CO 25
      • Antigen NY-CO-25
      • DKFZp686M05240
      • Heat shock 105kD
      • Heat shock 105kD alpha
      • Heat shock 105kD beta
      • Heat shock 105kDa protein
      • Heat shock 105kDa protein 1
      • Heat shock 105kDa/110kDa protein 1
      • Heat shock 110 kDa protein
      • Heat shock 110kDa protein
      • Heat shock protein 105 kDa
      • HS105_HUMAN
      • HSP105
      • HSP105A
      • HSP105B
      • HSP110
      • HSPH 1
      • Hsph1
      • KIAA0201
      • NY CO 25
      see all

    • Function

      Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.

    • Tissue specificity

      Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

    • Sequence similarities

      Belongs to the heat shock protein 70 family.

    • Post-translational
      modifications

      Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

    • Cellular localization

      Cytoplasm.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human Hsp105/HSP110 protein (ab78790)
      SDS-PAGE - Recombinant Human Hsp105/HSP110 protein (ab78790)
      12% SDS-PAGE showing ab78790 at approximately 100kDa (3µg).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (1)

    Publishing research using ab78790? Please let us know so that we can cite the reference in this datasheet.

    ab78790 has been referenced in 1 publication.

    • Labrador-Garrido A  et al. Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the a-synuclein-elicited immune response. FASEB J 30:564-77 (2016). PubMed: 26443817

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    Submitted Jan 25 2018

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