Description

  • Product name

    Recombinant Human htrA1 protein (His tag)
    See all htrA1 proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      DPNSLRHKYN FIADVVEKIA PAVVHIELFR KLPFSKREVP VASGSGFIVS EDGLIVTNAH VVTNKHRVKV ELKNGATYEA KIKDVDEKAD IALIKIDHQG KLPVLLLGRS SELRPGEFVV AIGSPFSLQN TVTTGIVSTT QRGGKELGLR NSDMDYIQTD AIINYGNSGG PLVNLDGEVI GINTLKVTAG ISFAIPSDKI KKFLTESHDR QAKGKAITKK KYIGIRMMSL TSSKAKELKD RHRDFPDVIS GAYIIEVIPD TPAEAGGLKE NDVIISINGQ SVVSANDVSD VIKRESTLNM VVRRGNEDIM ITVIPEEIDP
    • Predicted molecular weight

      38 kDa including tags
    • Amino acids

      161 to 480
    • Tags

      His tag N-Terminus
    • Additional sequence information

      NM_002775

Specifications

Our Abpromise guarantee covers the use of ab217834 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8.0
    Preservative: 1.02% Imidazole
    Constituents: 0.79% Tris HCl, 1.74% Sodium chloride, 10% Glycerol

General Info

  • Alternative names

    • ARMD7
    • CARASIL
    • High-temperature requirement A serine peptidase 1
    • HtrA
    • HtrA serine peptidase 1
    • HTRA1
    • HTRA1_HUMAN
    • IGFBP5 protease
    • L56
    • ORF480
    • protease serine 11
    • Protease serine 11 (IGF binding)
    • PRSS11
    • Serine protease 11
    • Serine protease HTRA1
    • Serine protease HTRA1 precursor
    see all
  • Function

    Protease that regulate the availability of nsulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Represses signaling by TGF-beta family members.
  • Tissue specificity

    Expressed in a variety of tissues, with strongest expression in placenta.
  • Involvement in disease

    Variations in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7) [MIM:610149]. ARMD is the leading cause of vision loss and blindness among older individuals in the developed word. It is classified as either dry (nonneovascular) or wet (neovascular). ARMD7 is a wet form, in which new blood vessels form and break beneath the retina. This leakage causes permanent damage to surrounding retinal tissue, distorting and destroying central vision. Wet ARMD is more prevalent among Asians than Caucasians.
    Defects in HTRA1 are the cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) [MIM:600142]. CARASIL is characterized by nonhypertensive cerebral small-vessel arteriopathy with subcortical infarcts, alopecia, and spondylosis, with an onset in early adulthood. On neuropathological examination, arteriosclerosis associated with intimal thickening and dense collagen fibers, loss of vascular smooth-muscle cells, and hyaline degeneration of the tunica media has been observed in cerebral small arteries.
  • Sequence similarities

    Belongs to the peptidase S1B family.
    Contains 1 IGFBP N-terminal domain.
    Contains 1 Kazal-like domain.
    Contains 1 PDZ (DHR) domain.
  • Cellular localization

    Secreted.
  • Information by UniProt

Images

  • SDS-PAGE image labeling htrA1 with ab217834

References

ab217834 has not yet been referenced specifically in any publications.

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