Recombinant Human ICOS protein (Fc Chimera) (ab206441)
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Description
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Product name
Recombinant Human ICOS protein (Fc Chimera)
See all ICOS proteins and peptides -
Purity
> 90 % SDS-PAGE. -
Endotoxin level
< 1.000 Eu/µg -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
EINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKG SGNTVSIKS LKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPP FKVTLTGGYLHIYESQLCCQ LKIEGRMDPKSCDKTHTCPPCPAPELLG GPSVFLFPPKPKDTLMISRTPEVTCVVVDVS HEDPEVKFNWYVDGVEV HNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVS NKALPAPI EKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE S NGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKS LSLSPGK -
Predicted molecular weight
40 kDa including tags -
Amino acids
21 to 140 -
Additional sequence information
The protein fragment is fused to Fc region of Human IgG1 at the C terminus.
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Associated products
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Related Products
Specifications
Our Abpromise guarantee covers the use of ab206441 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Liquid -
Additional notes
Protein may be diluted to ≥ 100 µg/ml in PBS + glycerol.
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Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -80°C. Avoid freeze / thaw cycle.
pH: 8.00
Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 20% Glycerol
General Info
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Alternative names
- Activation inducible lymphocyte immunomediatory molecule
- Activation-inducible lymphocyte immunomediatory molecule
- AILIM
see all -
Function
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. -
Tissue specificity
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. -
Involvement in disease
Immunodeficiency, common variable, 1 -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Post-translational
modificationsN-glycosylated. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human ICOS protein (Fc Chimera) (ab206441)4-20% SDS-PAGE stained with Coomassie Blue.
Lane 1: ab206441 (3 µg)
Lane 2: Protein MarkerNote: This protein runs at a higher MW by SDS-PAGE due to glycosylation.
Datasheets and documents
References
ab206441 has not yet been referenced specifically in any publications.
