Overview

  • Product name

    Recombinant Human IDH3B protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Amino acids

      90 to 378
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity

    = 90 % Purified via His tag.

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration

General Info

  • Alternative names

    • FLJ11043
    • H-IDHB
    • Idh3B
    • IDH3B_HUMAN
    • Isocitrate dehydrogenase [NAD] subunit beta
    • Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    • isocitrate dehydrogenase 3, beta subunit
    • Isocitric dehydrogenase
    • Isocitric dehydrogenase subunit beta
    • MGC903
    • mitochondrial
    • NAD(+)-specific ICDH
    • NAD(+)-specific ICDH subunit beta
    • NAD+-specific isocitrate dehydrogenase b subunit
    • NAD+-specific isocitrate dehydrogenase beta
    • OTTHUMP00000030023
    • OTTHUMP00000030024
    • RP46
    see all
  • Involvement in disease

    Defects in IDH3B are the cause of retinitis pigmentosa type 46 (RP46) [MIM:612572]. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similarities

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt

References

ab127861 has not yet been referenced specifically in any publications.

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