Recombinant Human IFN gamma Receptor beta/AF-1 protein (ab152472)

Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWE PVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAAS PSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTP GEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLD NLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVIL ISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQ PILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
    • Molecular weight

      63 kDa including tags
    • Amino acids

      1 to 337

Associated products

Specifications

Our Abpromise guarantee covers the use of ab152472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 µg/µl.

    Previously labelled as IFN gamma Receptor beta. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • AF 1
    • AF-1
    • AF1
    • IFGR 2
    • IFGR2
    • IFN gamma Receptor beta
    • IFN-gamma receptor 2
    • IFN-gamma-R2
    • IFNGR 2
    • IFNGR2
    • IFNGT 1
    • IFNGT1
    • IMD28
    • INGR2_HUMAN
    • Interferon gamma receptor 2
    • Interferon gamma receptor 2 (interferon gamma transducer 1)
    • Interferon gamma receptor accessory factor 1
    • Interferon gamma receptor beta chain
    • Interferon gamma receptor chain 2
    • Interferon gamma transducer 1
    see all
  • Function

    Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
  • Involvement in disease

    Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • Sequence similarities

    Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab152472 stained with Coomassie Blue.

References

ab152472 has not yet been referenced specifically in any publications.

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