Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWA IRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGL LAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFK ISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVP TQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGT SEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIE HETGTKITISSLQDLSIYNPERTITVKGTVEACASAEIEIMKKLREAFEN DMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTT HSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIK QLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENF FNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTP DENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQKYPQGVASQRSK
    • Amino acids

      1 to 598
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.

    Previously labelled as IGF2BP2. 

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • Hepatocellular carcinoma autoantigen p62
    • IF2B2_HUMAN
    • IGF 2 mRNA binding protein 2
    • IGF II mRNA binding protein 2
    • IGF-II mRNA-binding protein 2
    • IGF2 mRNA-binding protein 2
    • Igf2bp2
    • IMP 2
    • IMP-2
    • IMP2
    • Insulin like growth factor 2 mRNA binding protein 2
    • Insulin-like growth factor 2 mRNA-binding protein 2
    • OTTHUMP00000082606
    • OTTHUMP00000082607
    • OTTHUMP00000082608
    • p62
    • VICKZ 2
    • VICKZ family member 2
    • VICKZ2
    see all
  • Function

    Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs.
  • Tissue specificity

    Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
  • Sequence similarities

    Belongs to the RRM IMP/VICKZ family.
    Contains 4 KH domains.
    Contains 2 RRM (RNA recognition motif) domains.
  • Domain

    The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA.
  • Cellular localization

    Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa.
  • Information by UniProt

Images

  • ab153107 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153107 has not yet been referenced specifically in any publications.

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