Description

  • Product name

    Recombinant human IL-10RA protein (Fc Chimera)
    See all IL-10RA proteins and peptides
  • Biological activity

    Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

    < 5.000 Eu/mg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      HGTELPSPP SVWFEAEFFH HILHWTPIPN QSESTCYEVA LLRYGIESWN SISNCSQTLS YDLTAVTLDL YHSNGYRARV RAVDGSRHSN WTVTNTRFSV DEVTLTVGSV NLEIHNGFIL GKIQLPRPKM APANDTYESI FSHFREYEIA IRKVPGNFTF THKKVKHENF SLLTSGEVGE FCVQVKPSVA SRSNKGMWSK EECISLTRQY FTVTN
    • Predicted molecular weight

      24 kDa
    • Amino acids

      22 to 235
    • Additional sequence information

      Extracellular domain fused to the N-terminus of the Fc region of human IgG1 (AAH28082.1).

Specifications

Our Abpromise guarantee covers the use of ab214604 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute vial with 50 µl sterile water to a concentration of 1mg/ml. Add 1X PBS to the desired protein concentration.

General Info

  • Alternative names

    • CD210
    • CDw210a
    • CDw210a antigen
    • HIL 10R
    • HIL10R
    • I10R1_HUMAN
    • IL 10R
    • IL 10R 1
    • IL 10R A
    • IL 10R1
    • IL-10 receptor subunit alpha
    • IL-10R subunit 1
    • IL-10R subunit alpha
    • IL-10R1
    • IL-10RA
    • IL10R
    • IL10R1
    • IL10RA
    • Interleukin 10 receptor alpha
    • Interleukin 10 receptor alpha chain
    • Interleukin-10 receptor subunit 1
    • Interleukin-10 receptor subunit alpha
    see all
  • Function

    Receptor for IL10; binds IL10 with a high affinity.
  • Tissue specificity

    Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.
  • Involvement in disease

    Inflammatory bowel disease 28
  • Sequence similarities

    Belongs to the type II cytokine receptor family.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab214604 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab214604.
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