Bioactive grade

Recombinant human IL-17A protein (Active) (ab256041)

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Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level: < 1.000 Eu/µg
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human IL-17A protein (Active)
    See all IL-17A proteins and peptides

  • Biological activity

    Production of IL-6 from mouse NIH/3T3 cells. ED50≤10 ng/mL corresponding to a specific activity of ≥1.0 x 105 units/mg.

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    Escherichia coli

  • Accession

    Q16552

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYN RSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQE ILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA

    • Predicted molecular weight

      16 kDa

    • Amino acids

      21 to 155

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab256041 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at room temperature. Store at -20°C.

      Constituent: 0.1% Trifluoroacetic acid

      0.2 micron filtered

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute in sterile water to 0.1 mg/ml, Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws.

    General Info

    • Alternative names

      • CTLA 8
      • CTLA-8
      • CTLA8
      • cytotoxic T lymphocyte associated antigen 8
      • Cytotoxic T lymphocyte associated protein 8
      • Cytotoxic T lymphocyte associated serine esterase 8
      • Cytotoxic T-lymphocyte-associated antigen 8
      • IL 17
      • IL 17A
      • IL-17
      • IL-17A
      • IL17
      • IL17_HUMAN
      • Il17a
      • Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8)
      • interleukin 17A
      • Interleukin-17A
      • interleukin17
      • Interleukin17A
      • OTTHUMP00000016597
      • OTTMUSP00000046003
      see all

    • Function

      Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.

    • Tissue specificity

      Restricted to activated memory T-cells.

    • Sequence similarities

      Belongs to the IL-17 family.

    • Post-translational
      modifications

      Found both in glycosylated and nonglycosylated forms.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant human IL-17A protein (ab256041)
      SDS-PAGE - Recombinant human IL-17A protein (ab256041)

      SDS-PAGE analysis of ab256041 (1μg) under non-reducing (Lane 1) and reducing (Lane 2) conditions. ab256041 is a homodimer with predicted to have a MW of 31.3 kDa.

      4-20% Tris-Glycine gel. Coomassie Blue staining.

    • Functional Studies - Recombinant human IL-17A protein (ab256041)
      Functional Studies - Recombinant human IL-17A protein (ab256041)

      Functional analysis of ab256041.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab256041? Please let us know so that we can cite the reference in this datasheet.

    ab256041 has not yet been referenced specifically in any publications.

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