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    recombinant-human-il-1racp-protein-ab157075.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Recombinant Human IL-1RAcP protein (ab157075)

  • Datasheet
  • SDS
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Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level: < 0.100 Eu/µg
  • Suitable for: SDS-PAGE

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Description

  • Product name

    Recombinant Human IL-1RAcP protein
    See all IL-1RAcP proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

    < 0.100 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

    Q9NPH3
  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      SERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIW YWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSS VKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENG RTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYF SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKK VTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRY
    • Predicted molecular weight

      80 kDa
    • Amino acids

      21 to 356

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab157075 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C.

      Constituent: 99% PBS

    • Reconstitution
      Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

    General Info

    • Alternative names

      • C3orf13
      • FLJ37788
      • IL 1 receptor accessory protein
      • IL 1R 3
      • IL 1R3
      • IL 1RAcP
      • IL 1RAP
      • IL-1 receptor accessory protein
      • IL-1R-3
      • IL-1R3
      • IL-1RAcP
      • IL-1RAP
      • IL1 receptor accessory protein
      • IL1AP_HUMAN
      • IL1R3
      • IL1RAcP
      • Il1rap
      • Interleukin 1 Accessory Protein
      • interleukin 1 receptor 3
      • Interleukin 1 receptor accessory protein
      • interleukin 1 receptor accessory protein beta
      • Interleukin-1 receptor 3
      • Interleukin-1 receptor accessory protein
      see all
    • Function

      Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
    • Tissue specificity

      Detected in liver, skin, placenta, thymus and lung.
    • Sequence similarities

      Belongs to the interleukin-1 receptor family.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 TIR domain.
    • Cellular localization

      Secreted and Cell membrane.
    • Target information above from: UniProt accession Q9NPH3 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab157075? Please let us know so that we can cite the reference in this datasheet.

    ab157075 has not yet been referenced specifically in any publications.

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