Recombinant Human IL-1RAcP protein (ab157075)

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Overview

Description

  • Nature
    Recombinant
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
      Q9NPH3
    • Species
      Human
    • Sequence
      SERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIW YWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSS VKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENG RTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYF SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKK VTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRY
    • Molecular weight
      80 kDa
    • Amino acids
      21 to 356

Specifications

Our Abpromise guarantee covers the use of ab157075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    >95% by SDS-PAGE .

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

    Constituent: 99% PBS

  • Reconstitution
    Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Info

  • Alternative names
    • C3orf13
    • FLJ37788
    • IL 1 receptor accessory protein
    • IL 1R 3
    • IL 1R3
    • IL 1RAcP
    • IL 1RAP
    • IL-1 receptor accessory protein
    • IL-1R-3
    • IL-1R3
    • IL-1RAcP
    • IL-1RAP
    • IL1 receptor accessory protein
    • IL1AP_HUMAN
    • IL1R3
    • IL1RAcP
    • Il1rap
    • Interleukin 1 Accessory Protein
    • interleukin 1 receptor 3
    • Interleukin 1 receptor accessory protein
    • interleukin 1 receptor accessory protein beta
    • Interleukin-1 receptor 3
    • Interleukin-1 receptor accessory protein
    see all
  • Function
    Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
  • Tissue specificity
    Detected in liver, skin, placenta, thymus and lung.
  • Sequence similarities
    Belongs to the interleukin-1 receptor family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 TIR domain.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt

References

ab157075 has not yet been referenced specifically in any publications.

Publishing research using ab157075? Please let us know so that we can cite the reference in this datasheet.

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