Description

  • Product name

    Recombinant Human IL-21R protein (Fc Chimera)
    See all IL-21R proteins and peptides
  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

    < 0.060 Eu/µg
  • Expression system

    CHO cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      CPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHR SAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIK PAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAV SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSD PVIFQTQSEELKE
    • Predicted molecular weight

      25 kDa
    • Amino acids

      20 to 232
    • Additional sequence information

      The extracellular domain of Human IL-21Receptor fused to the N-terminus of the Fc region of Human IgG1 (NP_851564.1).

Specifications

Our Abpromise guarantee covers the use of ab214127 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C. Avoid freeze / thaw cycle.

    Constituent: 100% PBS

    0.2µm-filtered.

  • Reconstitution
    Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

General Info

  • Alternative names

    • CD360
    • IL 21R
    • IL-21 receptor
    • IL-21R
    • IL21 receptor
    • IL21R
    • IL21R_HUMAN
    • Interleukin 21 receptor
    • Interleukin-21 receptor
    • MGC10967
    • NILR
    • Novel interleukin receptor
    see all
  • Function

    This is a receptor for interleukin-21.
  • Tissue specificity

    Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 4 subfamily.
    Contains 2 fibronectin type-III domains.
  • Domain

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Post-translational
    modifications

    C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab214127 has not yet been referenced specifically in any publications.

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