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    recombinant-human-il-36rn-protein-ab151905.pdf

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Immunology Innate Immunity Cytokines Interleukins
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Recombinant Human IL-36RN protein (ab151905)

  • Datasheet
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Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level: < 1.000 Eu/µg
  • Suitable for: SDS-PAGE, HPLC

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ELISA
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Human IL36RN ELISA kit (ab267599)

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Description

  • Product name

    Recombinant Human IL-36RN protein
    See all IL-36RN proteins and peptides
  • Purity

    > 95 % SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    Escherichia coli
  • Accession

    Q9UBH0
  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWL DASLSPVILGVQGGSQCLSCGVGQEPTLTLEPVNIMELYLGAKESKSFTF YRRDMGLTSSFESAAYPGWFLCTVPEADQPVRLTQLPENGGWNAPITDFY FQQCD
    • Predicted molecular weight

      17 kDa
    • Amino acids

      1 to 155

Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab151905 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      HPLC

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

      pH: 7.50
      Constituents: 0.32% Tris HCl, 0.88% Sodium chloride

    • Reconstitution
      Lyophilized from a 0.2 µM filtered solution. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
      Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

    General Info

    • Alternative names

      • AI413231
      • Family of interleukin 1 delta
      • FIL1
      • FIL1 delta
      • FIL1(DELTA)
      • FIL1D
      • Fil1delta
      • I36RA_HUMAN
      • IL 1 delta
      • IL 1 related protein 3
      • IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta)
      • Il 1h3
      • IL 1HY1
      • IL 1L1
      • IL 1ra homolog
      • IL 1ra homolog; IL1F5 (Canonical product IL 1F5a)
      • IL 1RP3
      • IL-1 delta
      • IL-1-related protein 3
      • IL-1F5
      • IL-1HY1
      • IL-1L1
      • IL-1ra homolog 1
      • IL-1RP3
      • IL1F5
      • IL1HY1
      • IL1L1
      • IL1RP3
      • IL36RA
      • IL36RN
      • Interleukin 1 delta
      • Interleukin 1 family member 5
      • Interleukin 1 family member 5 (delta)
      • Interleukin 1 HY1
      • Interleukin 1 like protein 1
      • Interleukin 1 receptor antagonist homolog 1
      • Interleukin 36 receptor antagonist
      • Interleukin-1 delta
      • Interleukin-1 family member 5
      • Interleukin-1 HY1
      • Interleukin-1 receptor antagonist homolog 1
      • Interleukin-1-like protein 1
      • Interleukin-36 receptor antagonist protein
      • MGC29840
      • PSORP
      • RP23-176J12.6
      see all
    • Function

      Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
    • Tissue specificity

      Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
    • Involvement in disease

      Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
    • Sequence similarities

      Belongs to the IL-1 family.
    • Cellular localization

      Secreted.
    • Target information above from: UniProt accession Q9UBH0 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab151905? Please let us know so that we can cite the reference in this datasheet.

    ab151905 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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