Product nameRecombinant Human IL-6R protein
See all IL-6R proteins and peptides
Purity> 95 % SDS-PAGE.
Expression systemEscherichia coli
Protein lengthProtein fragment
Amino acids20 to 357
- Anti-6X His tag® antibody (HRP) (ab1187)
- Anti-6X His tag® antibody (FITC) (ab1206)
- Anti-6X His tag® antibody (HRP) (ab1269)
- Anti-6X His tag® antibody [AD1.1.10] (Biotin) (ab15145)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-6X His tag® antibody [HIS-1] (Alkaline Phosphatase) (ab49746)
- Anti-6X His tag® antibody (ab9108)
- Anti-6X His tag® antibody (ab9136)
Our Abpromise guarantee covers the use of ab53370 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.242% Tris, 50% Glycerol
- CD 126
- CD126 antigen
FunctionPart of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Tissue specificityIsoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 3 subfamily.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
DomainThe two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
modificationsA short soluble form may also be released from the membrane by proteolysis.
Cellular localizationSecreted and Basolateral cell membrane.
- Information by UniProt
ab53370 has not yet been referenced specifically in any publications.