Product nameRecombinant Human IL-6R protein
See all IL-6R proteins and peptides
Purity> 95 % SDS-PAGE.
Expression systemEscherichia coli
Protein lengthProtein fragment
Amino acids20 to 357
- Anti-6X His tag® antibody (HRP) (ab1187)
- Anti-6X His tag® antibody (FITC) (ab1206)
- Anti-6X His tag® antibody (HRP) (ab1269)
- Anti-6X His tag® antibody [AD1.1.10] (Biotin) (ab15145)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-6X His tag® antibody [HIS-1] (Alkaline Phosphatase) (ab49746)
- Anti-6X His tag® antibody (ab9108)
- Anti-6X His tag® antibody (ab9136)
Our Abpromise guarantee covers the use of ab53370 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituents: 0.242% Tris, 50% Glycerol
- CD 126
- CD126 antigen
FunctionPart of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Tissue specificityIsoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 3 subfamily.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
DomainThe two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
modificationsA short soluble form may also be released from the membrane by proteolysis.
Cellular localizationSecreted and Basolateral cell membrane.
- Information by UniProt
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab53370 has not yet been referenced specifically in any publications.