The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
The ED50 as determined by the dose-dependent stimulation of Human TF-1 cells is = 0.2 ng/ml, corresponding to a specific activity of = 5 x 106 units/mg.
< 1.000 Eu/µg
% SDS-PAGE. >98% by SDS PAGE and HPLC
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Preparation and Storage
Stability and Storage
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Note: Buffer prior to lyophilisation is water with trace amounts of 0.1% TCA
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute with 50ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. It is recommended that the vial is gently mixed after reconstitution.
B cell growth factor 1
B cell IgG differentiation factor
B Cell Stimulatory Factor 1
B-cell stimulatory factor 1
IGG1 induction factor
Interleukin 4 variant 2
Interleukin 4, isoform 1
Lymphocyte stimulatory factor 1
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
Involvement in disease
Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.