Description

  • Product name

    Recombinant Human IMPDH1 protein
  • Purity

    > 95 % SDS-PAGE.
    ab97410 is purified using conventional chromatography techniques.
  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MGSSHHHHHH SSGLVPRGSH MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY
    • Predicted molecular weight

      58 kDa including tags
    • Amino acids

      1 to 514
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab97410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF-TOF
  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.0154% DTT, 0.316% Tris HCl, 20% Glycerol

General Info

  • Alternative names

    • IMDH1_HUMAN
    • IMP (inosine monophosphate) dehydrogenase 1
    • IMP dehydrogenase 1
    • IMPD
    • IMPD 1
    • IMPD1
    • IMPDH 1
    • IMPDH I
    • IMPDH-I
    • Impdh1
    • Inosine 5' monophosphate dehydrogenase 1
    • Inosine monophosphate dehydrogenase 1
    • Inosine-5''-monophosphate dehydrogenase 1
    • LCA11
    • RP10
    • sWSS2608
    see all
  • Function

    Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • Tissue specificity

    IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • Pathway

    Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • Involvement in disease

    Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • Sequence similarities

    Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab97410 at approximately 57.5kDa (3µg).

References

ab97410 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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