Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      Q5XLA6
    • Species
      Human
    • Sequence
      MGSSHHHHHHSSGLVPRGSHMGSMADKVLKEKRKQFIRSVGEGTINGLLG ELLETRVLSQEEIEIVKCENATVMDKARALLDSVIRKGAPACQICITYIC EEDSHLAGTLGLSAGPTSGNHLTTQDSQIVLPS
    • Molecular weight
      14 kDa including tags
    • Amino acids
      1 to 110
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    >95% by SDS-PAGE .
    ab171673 was purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • CAR17_HUMAN
    • CARD 17
    • CARD17
    • Caspase 1 inhibitor
    • Caspase recruitment domain containing protein 17
    • Caspase recruitment domain-containing protein 17
    • Caspase-1 inhibitor INCA
    • Caspase1 inhibitor
    • Inhibitory caspase recruitment domain (CARD) protein
    • Inhibitory caspase recruitment domain protein
    see all
  • Function
    Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 CARD domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

Images

  • SDS-PAGE - INCA protein (His tag) (ab171673)
    SDS-PAGE - INCA protein (His tag) (ab171673)
    15% SDS-PAGE analysis of ab171673 (3µg).

References

ab171673 has not yet been referenced specifically in any publications.

Publishing research using ab171673? Please let us know so that we can cite the reference in this datasheet.

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