Overview

  • Product name

    Recombinant Human INF2 protein
  • Protein length

    Protein fragment

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      21 kDa
    • Amino acids

      44 to 224
    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127238 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Additional notes

     This product was previously labelled as C14orf151

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • C14orf151
    • C14orf173
    • CMTDIE
    • DKFZp762A0214
    • FLJ22056
    • FSGS5
    • HBEAG binding protein 2 binding protein C
    • HBEBP2 binding protein C
    • HBEBP2-binding protein C
    • INF 2
    • inf2
    • INF2_HUMAN
    • Inverted formin 2
    • Inverted formin FH2 and WH2 domain containing
    • Inverted formin-2
    • MGC13251
    • pp9484
    see all
  • Function

    Severs actin filaments and accelerates their polymerization and depolymerization.
  • Tissue specificity

    Widely expressed. In the kidney, expression is apparent in podocytes and some tubule cells.
  • Involvement in disease

    Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5) [MIM:613237]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • Sequence similarities

    Belongs to the formin homology family.
    Contains 1 FH2 (formin homology 2) domain.
    Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
    Contains 1 WH2 domain.
  • Domain

    The WH2 domain acts as the DAD (diaphanous autoregulatory) domain and binds to actin monomers.
    Regulated by autoinhibition due to intramolecular GBD-DAD binding.
    The severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus.
  • Cellular localization

    Cytoplasm > perinuclear region.
  • Information by UniProt

References

ab127238 has not yet been referenced specifically in any publications.

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