Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMLGQQQQ QLYSSAALLT GERSRLLTCY VQDYLECVES LPHDMQRNVS VLRELDNKYQ ETLKEIDDVY EKYKKEDDLN QKKRLQQLLQ RALINSQELG DEKIQIVTQM LELVENRARQ MELHSQCFQD PAESERASDK AKMDSSQPER SSRRPRRQRT SESRDLCHMA NGIEDCDDQP PKEKKSKSAK KKKRSKAKQE REASPVEFAI DPNEPTYCLC NQVSYGEMIG CDNEQCPIEW FHFSCVSLTY KPKGKWYCPK CRGDNEKTMD KSTEKTKKDR RSR
    • Molecular weight
      35 kDa including tags
    • Amino acids
      1 to 280
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.
    ab171499 is purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • ING 1 like tumor suppressor protein
    • ING 1L
    • ING 2
    • ING1 like tumor suppressor protein
    • ING1L
    • ING1Lp
    • ING2
    • ING2_HUMAN
    • Inhibitor of growth 1 like
    • Inhibitor of growth 1 like protein
    • Inhibitor of growth 1-like protein
    • Inhibitor of growth family member 1 like
    • Inhibitor of growth family member 2
    • Inhibitor of growth protein 2
    • p32
    • p33 ING2
    • p33ING2
    see all
  • Function
    Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
  • Tissue specificity
    Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
  • Sequence similarities
    Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • Domain
    The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
  • Cellular localization
    Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab171499 (3µg).

References

ab171499 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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