Recombinant Human Interferon alpha/beta receptor 1 protein (ab151659)

Overview

Description

  • Nature

    Recombinant
  • Source

    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLS GCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQ IGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVE ERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVEN ELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKW KQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTE IQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENT SNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCE KTKPGNTSKLD
    • Amino acids

      28 to 436
    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab151659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Endotoxin level

    < 1.000 Eu/µg
  • Purity

    > 95 % SDS-PAGE.

  • Form

    Lyophilised
  • Additional notes

    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.20
    Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles

General Info

  • Alternative names

    • Alpha type antiviral protein
    • Antiviral protein, alpha-type
    • Antiviral protein, beta-type
    • AVP
    • Beta type antiviral protein
    • CRF2-1
    • Cytokine receptor class-II member 1
    • Cytokine receptor family 2 member 1
    • IFN alpha REC
    • IFN alpha receptor
    • IFN alpha/beta Receptor alpha
    • IFN beta receptor
    • IFN Interferon-beta receptor
    • IFN-alpha/beta receptor 1
    • IFN-R-1
    • IFNAR
    • Ifnar1
    • IFNBR
    • IFRC
    • INAR1_HUMAN
    • Interferon (alpha beta and omega) receptor 1
    • interferon alpha and beta receptor subunit 1
    • Interferon alpha/beta receptor 1
    • Interferon alpha/beta receptor alpha chain
    • Interferon beta receptor 1
    • interferon receptor 1
    • Interferon-alpha receptor
    • Type I interferon receptor 1
    see all
  • Function

    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
  • Tissue specificity

    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
  • Sequence similarities

    Belongs to the type II cytokine receptor family.
    Contains 3 fibronectin type-III domains.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
  • Cellular localization

    Membrane.
  • Information by UniProt

References

ab151659 has not yet been referenced specifically in any publications.

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