Recombinant Human Interferon alpha/beta receptor 1 protein (Fc Chimera) (ab219671)

Description

  • Product name

    Recombinant Human Interferon alpha/beta receptor 1 protein (Fc Chimera)
    See all Interferon alpha/beta receptor 1 proteins and peptides
  • Purity

    = 85 % SDS-PAGE.
    85% (rh IFNAR1 /IFNAR Fc Chimera) and 13% (Human IgG1 Fc fragment) as determined by SDS-PAGE.
  • Endotoxin level

    < 1.000 Eu/µg
  • Expression system

    HEK 293 cells
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      KNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGMDNWIKLS GCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQ IGPPEVHLEAEDKAIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVE ERIENIYSRHKIYKLSPETTYCLKVKAALLTSWKIGVYSPVHCIKTTVEN ELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKW KQIPDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTE IQAFLLPPVFNIRSLSDSFHIYIGAPKQSGNTPVIQDYPLIYEIIFWENT SNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSVFSDAVCE KTKPGNTSK
    • Predicted molecular weight

      74 kDa including tags
    • Amino acids

      28 to 436
    • Additional sequence information

      Extracellular domain fused to a human IgG1 Fc tag at the C-terminal.

Specifications

Our Abpromise guarantee covers the use of ab219671 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 7.50
    Constituents: 0.75% Glycine, 0.61% Tris buffer, 5% Trehalose, L-Arginine, Sodium chloride

    Lyophilized from 0.22 µm filtered solution.

  • Reconstitution
    It is recommended to reconstitute the lyophilized product in 100 µl sterile deionized water to a final concentration of 1 mg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.

General Info

  • Alternative names

    • Alpha type antiviral protein
    • Antiviral protein, alpha-type
    • Antiviral protein, beta-type
    • AVP
    • Beta type antiviral protein
    • CRF2-1
    • Cytokine receptor class-II member 1
    • Cytokine receptor family 2 member 1
    • IFN alpha REC
    • IFN alpha receptor
    • IFN alpha/beta Receptor alpha
    • IFN beta receptor
    • IFN Interferon-beta receptor
    • IFN-alpha/beta receptor 1
    • IFN-R-1
    • IFNAR
    • Ifnar1
    • IFNBR
    • IFRC
    • INAR1_HUMAN
    • Interferon (alpha beta and omega) receptor 1
    • interferon alpha and beta receptor subunit 1
    • Interferon alpha/beta receptor 1
    • Interferon alpha/beta receptor alpha chain
    • Interferon beta receptor 1
    • interferon receptor 1
    • Interferon-alpha receptor
    • Type I interferon receptor 1
    see all
  • Function

    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
  • Tissue specificity

    IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
  • Sequence similarities

    Belongs to the type II cytokine receptor family.
    Contains 3 fibronectin type-III domains.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • The purity of ab219671 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

    DTT-reduced protein migrates as 110-120 kDa due to glycosylation.

References

ab219671 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab219671.
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