Product nameRecombinant Human Interferon gamma protein
See all Interferon gamma proteins and peptides
Protein lengthProtein fragment
Amino Acid Sequence
Amino acids24 to 166
- Anti-6X His tag® antibody (HRP) (ab1187)
- Anti-6X His tag® antibody (FITC) (ab1206)
- Anti-6X His tag® antibody (HRP) (ab1269)
- Anti-6X His tag® antibody [AD1.1.10] (Biotin) (ab15145)
- Anti-6X His tag® antibody [HIS.H8] (ab18184)
- Anti-6X His tag® antibody [HIS-1] (Alkaline Phosphatase) (ab49746)
- Anti-6X His tag® antibody - ChIP Grade (ab9108)
- Anti-6X His tag® antibody (ab9136)
Our Abpromise guarantee covers the use of ab53375 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Purity> 95 % SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- IFN gamma
FunctionProduced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Tissue specificityReleased primarily from activated T lymphocytes.
Involvement in diseaseIn Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
Sequence similaritiesBelongs to the type II (or gamma) interferon family.
modificationsProteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
- Information by UniProt
ab53375 has not yet been referenced specifically in any publications.