Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)

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SDS-PAGE - Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)

    Key features and details

    • Expression system: Baculovirus infected Sf9 cells
    • Purity: > 70% Densitometry
    • Suitable for: WB, SDS-PAGE

    Description

    • Product name

      Recombinant Human IPL-1/STK13/Aurora C protein
      See all IPL-1/STK13/Aurora C proteins and peptides

    • Purity

      > 70 % Densitometry.

    • Expression system

      Baculovirus infected Sf9 cells

    • Accession

      Q9UQB9

    • Protein length

      Full length protein

    • Animal free

      No

    • Nature

      Recombinant

      • Species

        Human

      • Predicted molecular weight

        36 kDa

      • Amino acids

        1 to 309

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab133139 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Western blot

      SDS-PAGE

    • Form

      Liquid
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 7.50
      Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

    General Info

    • Alternative names

      • AURKC
      • AIE 2
      • Aie1
      • AIE2
      • AIK 3
      • AIK3
      • ARK 3
      • ARK-3
      • ARK3
      • Aur C
      • AurC
      • Aurkc
      • AURKC_HUMAN
      • aurora 3
      • Aurora C
      • Aurora kinase C
      • aurora related kinase 3
      • Aurora-related kinase 3
      • Aurora/Ipl1 related kinase 3
      • Aurora/Ipl1-related kinase 3
      • Aurora/Ipl1/Eg2 protein 2
      • EC 2.7.11.1
      • Serine threonine protein kinase 13
      • serine/threonine kinase 13 (aurora/IPL1 like)
      • serine/threonine protein kinase aurora C
      • Serine/threonine-protein kinase 13
      • Serine/threonine-protein kinase aurora-C
      • SPGF5
      • STK13
      see all

    • Function

      May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.

    • Tissue specificity

      Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.

    • Involvement in disease

      Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.

    • Sequence similarities

      Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
      Contains 1 protein kinase domain.

    • Cellular localization

      Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
    • Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)
      SDS-PAGE - Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)
      SDS-PAGE analysis of ab133139.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab133139? Please let us know so that we can cite the reference in this datasheet.

    ab133139 has not yet been referenced specifically in any publications.

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