Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)

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Overview

Description

  • Nature

    Recombinant

  • Source

    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
      Q9UQB9

    • Species

      Human

    • Molecular weight

      36 kDa

    • Amino acids

      1 to 309

Specifications

Our Abpromise guarantee covers the use of ab133139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity

    > 70 % Densitometry.

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.005% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • AURKC
    • AIE 2
    • Aie1
    • AIE2
    • AIK 3
    • AIK3
    • ARK 3
    • ARK-3
    • ARK3
    • Aur C
    • AurC
    • Aurkc
    • AURKC_HUMAN
    • aurora 3
    • Aurora C
    • Aurora kinase C
    • aurora related kinase 3
    • Aurora-related kinase 3
    • Aurora/Ipl1 related kinase 3
    • Aurora/Ipl1-related kinase 3
    • Aurora/Ipl1/Eg2 protein 2
    • EC 2.7.11.1
    • Serine threonine protein kinase 13
    • serine/threonine kinase 13 (aurora/IPL1 like)
    • serine/threonine protein kinase aurora C
    • Serine/threonine-protein kinase 13
    • Serine/threonine-protein kinase aurora-C
    • SPGF5
    • STK13
    see all

  • Function

    May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. May also contribute to the regulation of chromosome segregation and cytokinesis.

  • Tissue specificity

    Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Expression is maximum at M phase.

  • Involvement in disease

    Defects in AURKC are the cause of male infertility with large-headed multiflagellar polyploid spermatozoa (MIMPS) [MIM:243060]; also known as infertility associated with multi-tailed spermatozoa and excessive DNA.

  • Sequence similarities

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
    Contains 1 protein kinase domain.

  • Cellular localization

    Chromosome. Cytoplasm > cytoskeleton > spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remaines in the midbody during cytokinesis.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)
    SDS-PAGE - Recombinant Human IPL-1/STK13/Aurora C protein (ab133139)
    SDS-PAGE analysis of ab133139.

References

ab133139 has not yet been referenced specifically in any publications.

Publishing research using ab133139? Please let us know so that we can cite the reference in this datasheet.

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