Description

  • Product name

    Recombinant Human IRAKM protein
    See all IRAKM proteins and peptides
  • Purity

    > 80 % SDS-PAGE.
    Assessed by densitometry.
  • Expression system

    Baculovirus infected Sf9 cells
  • Accession

  • Protein length

    Full length protein
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Predicted molecular weight

      96 kDa
    • Amino acids

      1 to 596

Specifications

Our Abpromise guarantee covers the use of ab125546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

General Info

  • Alternative names

    • ASRT5
    • IL 1 receptor associated kinase M
    • IL-1 receptor-associated kinase M
    • IL1 receptor associated kinase M
    • Interleukin 1 receptor associated kinase 3
    • Interleukin 1 receptor associated kinase M
    • Interleukin-1 receptor-associated kinase 3
    • IRAK M
    • IRAK-3
    • IRAK-M
    • Irak3
    • IRAK3_HUMAN
    see all
  • Function

    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
  • Tissue specificity

    Expressed predominantly in peripheral blood lymphocytes.
  • Involvement in disease

    Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

Images

  • SDS-PAGE analysis of ab125546.

References

ab125546 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab125546.
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