Overview

Description

  • Nature

    Recombinant
  • Source

    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Molecular weight

      18 kDa
    • Amino acids

      54 to 203
    • Tags

      His-DHFR tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab127839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • Reconstitution
    Reconstitute with water to desired concentration.

General Info

  • Alternative names

    • C6orf71
    • DEHAL1
    • dJ422F24.1
    • Iodotyrosine dehalogenase 1
    • iodotyrosine deiodinase
    • IYD
    • IYD-1
    • IYD1_HUMAN
    • OTTHUMP00000017973
    • OTTHUMP00000237263
    • OTTHUMP00000237264
    • OTTHUMP00000237265
    • OTTHUMP00000237266
    • OTTHUMP00000237267
    • TDH4
    see all
  • Function

    Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
  • Tissue specificity

    Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
  • Involvement in disease

    Defects in IYD are the cause of congenital hypothyroidism due to dyshormonogenesis type 4 (CHDH4) [MIM:274800]; also known as genetic defect in thyroid hormonogenesis type 4 or iodotyrosine dehalogenase deficiency or deiodinase deficiency. Patients with this defect present a phenotype of severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized hypothyroidism.
  • Sequence similarities

    Belongs to the nitroreductase family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt

References

ab127839 has not yet been referenced specifically in any publications.

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