Recombinant Human IYD protein (denatured) (ab177648)

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Description

  • Product name

    Recombinant Human IYD protein (denatured)
    See all IYD proteins and peptides

  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    Q6PHW0-3

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHHSSGLVPRGSHMGSDRSMEKKKGEPRTRAEARPWVDEDLKD SSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKR RSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIR KIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHG FAANGKKKVH YYNE

    • Predicted molecular weight

      25 kDa including tags

    • Amino acids

      24 to 214

    • Tags

      His tag N-Terminus

    • Additional sequence information

      Extracellular domain. NP_001158167.

Specifications

Our Abpromise guarantee covers the use of ab177648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Information available upon request.

General Info

  • Alternative names

    • C6orf71
    • DEHAL1
    • dJ422F24.1
    • Iodotyrosine dehalogenase 1
    • iodotyrosine deiodinase
    • IYD
    • IYD-1
    • IYD1_HUMAN
    • OTTHUMP00000017973
    • OTTHUMP00000237263
    • OTTHUMP00000237264
    • OTTHUMP00000237265
    • OTTHUMP00000237266
    • OTTHUMP00000237267
    • TDH4
    see all

  • Function

    Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.

  • Tissue specificity

    Expressed at a high level in thyroid gland and at lower level in kidney and trachea.

  • Involvement in disease

    Defects in IYD are the cause of congenital hypothyroidism due to dyshormonogenesis type 4 (CHDH4) [MIM:274800]; also known as genetic defect in thyroid hormonogenesis type 4 or iodotyrosine dehalogenase deficiency or deiodinase deficiency. Patients with this defect present a phenotype of severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized hypothyroidism.

  • Sequence similarities

    Belongs to the nitroreductase family.

  • Cellular localization

    Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human IYD protein (denatured) (ab177648)
    SDS-PAGE - Recombinant Human IYD protein (denatured) (ab177648)

    15% SDS-PAGE showing ab177648 (3 µg) at approximately 25.1 kDa.

References

ab177648 has not yet been referenced specifically in any publications.

Publishing research using ab177648? Please let us know so that we can cite the reference in this datasheet.

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