• Nature
  • Source
    HEK 293 cells
  • Amino Acid Sequence
    • Accession
    • Species
    • Molecular weight
      150 kDa including tags
    • Amino acids
      1 to 1067
    • Tags
      Fc tag C-Terminus
    • Additional sequence information
      Signal peptide and extracellular domain of human Jagged-1 (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.

Associated products


Our Abpromise guarantee covers the use of ab108575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
  • Applications

    Functional Studies


  • Endotoxin level
    < 0.100 Eu/µg
  • Purity
    > 90 % SDS-PAGE.
    ab108575 is 0.2µm filtered
  • Form
  • Additional notes
    Working aliquots are stable for up to 3 months when stored at -20°C. Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

General Info

  • Alternative names
    • AGS
    • AHD
    • AWS
    • CD 339
    • CD339
    • CD339 antigen
    • Headturner
    • hJ1
    • Htu
    • Jag 1
    • Jag1
    • JAG1_HUMAN
    • Jagged 1
    • Jagged1
    • Jagged1 (Alagille syndrome)
    • JAGL1
    • MGC104644
    • OTTHUMP00000030278
    • Protein jagged-1
    • Ser 1
    • Ser1
    • Serrate 1
    • Slalom
    see all
  • Function
    Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
  • Tissue specificity
    Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
  • Involvement in disease
    Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
    Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.
  • Sequence similarities
    Contains 1 DSL domain.
    Contains 15 EGF-like domains.
  • Developmental stage
    Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.
  • Cellular localization
  • Information by UniProt


  • Induction of Hes-1 with the treatment of recombinant Human Jagged1-Fc (ab108575).
    A mouse preadpipocyte cell line, 3T3L1, was stimulated with 5µg/ml of ab108575 as in indicated time points and each cell lysate was prepared and subjected to western blot by using anti-mouse Hes1 or GAPDH.

    M: Marker
    Lane 1: ab108575, 0 min
    Lane 2: ab108575, 10 min
    Lane 3: ab108575, 30 min
    Lane 4: ab108575, 1 hr
    Lane 5: ab108575, 2 hr
    Lane 6: ab108575, 4 hr
    Lane 7: ab108575, 8 hr
    Lane 8: ab108575, 24 hr


This product has been referenced in:
  • Tang D  et al. Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin ß1 in Keratinocyte Migration. Sci Rep 7:43926 (2017). Read more (PubMed: 28266574) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for contacting Abcam about ab108575.
We checked the concentration of the protein that you received internally and everything was ok. We assume that something happened during the preparation/aliquotting of the protein. I have sent you ano...

Read More

Thank you for contacting us.

While this product is indeedrecombinant Human Jagged1-Fc, we do not currently have a recommended protocol for yuse with this product. We encourage customers to consult the latest literature available throu...

Read More


Sign up