Overview

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species

      Human
    • Sequence

      MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWL VEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSAL MEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI
    • Molecular weight

      42 kDa including tags
    • Amino acids

      1 to 146

Specifications

Our Abpromise guarantee covers the use of ab132615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • hJT
    • HJTB
    • HSPC222
    • JTB
    • JTB_HUMAN
    • Jumping translocation breakpoint
    • Jumping translocation breakpoint protein
    • OTTHUMP00000034759
    • PAR
    • PAR protein
    • Prostate androgen regulated protein
    • Prostate androgen-regulated protein
    • Protein JTB
    see all
  • Function

    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.
  • Tissue specificity

    Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
  • Sequence similarities

    Belongs to the JTB family.
  • Cellular localization

    Membrane. Mitochondrion. Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE analysis of ab132615 stained with Coomassie Blue.

References

ab132615 has not yet been referenced specifically in any publications.

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