Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (ab126670)

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Description

  • Product name

    Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein
    See all Junctional Adhesion Molecule 1/JAM-A proteins and peptides

  • Purity

    > 90 % SDS-PAGE.
    ab126670 was purified using conventional chromatography.

  • Expression system

    Escherichia coli

  • Accession

    Q9Y624

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMLGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGV

    • Predicted molecular weight

      26 kDa including tags

    • Amino acids

      26 to 238

    • Tags

      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry

    MALDI-TOF

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names

    • CD 321
    • CD321
    • CD321 antigen
    • ESTM33
    • F11 receptor
    • F11R
    • JAM
    • JAM 1
    • JAM A
    • JAM-1
    • JAM-A
    • JAM1
    • JAM1_HUMAN
    • JAMA
    • JCAM
    • Jcam1
    • Junction adhesion molecule 1
    • Junction adhesion molecule, mouse, homolog of
    • Junctional adhesion molecule 1
    • Junctional adhesion molecule A
    • KAT
    • Ly106
    • PAM 1
    • PAM-1
    • PAM1
    • Platelet adhesion molecule
    • Platelet adhesion molecule 1
    • Platelet F11 receptor
    • PRO301
    • UNQ264
    see all

  • Function

    Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

  • Sequence similarities

    Belongs to the immunoglobulin superfamily.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.

  • Post-translational
    modifications

    N-glycosylated.

  • Cellular localization

    Cell junction > tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (ab126670)
    SDS-PAGE - Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (ab126670)
    15% SDS-PAGE analysis of ab126670 (3µg)

References

ab126670 has not yet been referenced specifically in any publications.

Publishing research using ab126670? Please let us know so that we can cite the reference in this datasheet.

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