Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (ab126670)

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Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
      Q9Y624
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSHMLGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGV
    • Molecular weight
      26 kDa including tags
    • Amino acids
      26 to 238
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab126670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF
  • Purity
    > 90 % SDS-PAGE.
    ab126670 was purified using conventional chromatography.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride

General Info

  • Alternative names
    • CD 321
    • CD321
    • CD321 antigen
    • ESTM33
    • F11 receptor
    • F11R
    • JAM
    • JAM 1
    • JAM A
    • JAM-1
    • JAM-A
    • JAM1
    • JAM1_HUMAN
    • JAMA
    • JCAM
    • Jcam1
    • Junction adhesion molecule 1
    • Junction adhesion molecule, mouse, homolog of
    • Junctional adhesion molecule 1
    • Junctional adhesion molecule A
    • KAT
    • Ly106
    • PAM 1
    • PAM-1
    • PAM1
    • Platelet adhesion molecule
    • Platelet adhesion molecule 1
    • Platelet F11 receptor
    • PRO301
    • UNQ264
    see all
  • Function
    Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily.
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Cell junction > tight junction. Cell membrane. Localized at tight junctions of both epithelial and endothelial cells.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (ab126670)
    SDS-PAGE - Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (ab126670)
    15% SDS-PAGE analysis of ab126670 (3µg)

References

ab126670 has not yet been referenced specifically in any publications.

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