Recombinant Human Kallikrein 11 protein (ab151649)

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Description

  • Product name

    Recombinant Human Kallikrein 11 protein
    See all Kallikrein 11 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    ab151649 was determined to be >95% pure by SEC-HPLC and reducing SDS-PAGE.

  • Endotoxin level

    < 1.000 Eu/µg

  • Expression system

    HEK 293 cells

  • Accession

    Q9UBX7

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      IIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVH LGQHNLQKEE GCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTL SSRCVTAGTS CLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASV QEGGKDSCQG DSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNNV DHHHHHH

    • Predicted molecular weight

      25 kDa

    • Amino acids

      54 to 282

    • Tags

      His tag C-Terminus

Specifications

Our Abpromise guarantee covers the use of ab151649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    HPLC

  • Form

    Liquid

  • Additional notes

    ab151649 was produced by a mammalian cell expression system in HEK293.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% Calcium chloride, 0.32% Tris HCl, 0.88% Sodium chloride

General Info

  • Alternative names

    • Hippostasin
    • hK11
    • Kallikrein 11
    • Kallikrein 11 isoform 1 preproprotein
    • Kallikrein 11 isoform 2 precursor
    • Kallikrein 11 precursor
    • Kallikrein related peptidase 11
    • Kallikrein-11 inactive chain 2
    • KLK 11
    • Klk11
    • KLK11_HUMAN
    • MGC33060
    • Protease serine 20 trypsin like
    • Protease serine trypsin like
    • PRSS20
    • Serine protease 20
    • TLSP
    • Trypsin like protease
    • Trypsin-like protease
    see all

  • Function

    Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

  • Tissue specificity

    Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).

  • Sequence similarities

    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.

  • Post-translational
    modifications

    About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.

  • Cellular localization

    Secreted.
  • Information by UniProt

References

ab151649 has not yet been referenced specifically in any publications.

Publishing research using ab151649? Please let us know so that we can cite the reference in this datasheet.

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