Recombinant Human Kallikrein 6 protein (ab82792)



  • Nature
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
    • Amino acids
      17 to 244

Associated products


Our Abpromise guarantee covers the use of ab82792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 7.00

  • Reconstitution
    500ul distilled water for reconstitution then 20mM HEPES, pH 7.0

General Info

  • Alternative names
    • Bssp
    • hK 6
    • hK6
    • Kallikrein 6 precursor
    • Kallikrein related peptidase 6
    • Kallikrein-6
    • Kallikrein6
    • KLK 6
    • Klk 7
    • KLK 9
    • Klk29
    • Klk6
    • KLK6_HUMAN
    • Klk7
    • KLK9
    • MGC9355
    • mGK 1
    • mGK1
    • MSP
    • Neurosin
    • Protease M
    • Protease serine 18
    • Protease serine 9
    • PRSS 18
    • PRSS 9
    • PRSS18
    • PRSS9
    • Serine protease 18
    • Serine protease 9
    • SP 59
    • SP59
    • Tissue kallikrein
    • TK
    • Zyme
    see all
  • Function
    Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
  • Tissue specificity
    In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
  • Sequence similarities
    Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • Post-translational
    Inactivated by autolytic cleavage after Arg-80.
  • Cellular localization
    Secreted. Nucleus > nucleolus. Cytoplasm. Mitochondrion. Microsome. In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
  • Information by UniProt


  • SDS-PAGE showing ab82792 at approximately 51.8kDa.


ab82792 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


Review text: Ab82792 is a recombinant full length human Kallikrein 6, which was loaded and co-electrophoresed along with the Western C marker (BioRad) for 50 min and then the gel was stained with Coomassie Blue Staining and the membrane was stained with Ponceau S in order to visualise this protein on the gel and the membrane.
Sample: Human Recombinant protein

Primary antibody (in addition to 'Kallikrein 6 protein (Tagged)')
Primary antibody: None used

Secondary antibody
Secondary antibody: None used

Abcam user community

Verified customer

Submitted Oct 23 2012

Thank you for contacting us last week in regards to the Kallikrein 6 protein (ab82792).

I am sorry for the confusion caused by the datasheet for this product. I can now explain how the protein should be reconstituted. You need to add 500 &mic...

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