Description

  • Product name

    Recombinant Human KAT2A / GCN5 protein (Tagged-His Tag)
    See all KAT2A / GCN5 proteins and peptides
  • Purity

    > 99 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MHHHHHHLKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVI RFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCAS ALEKFFYFKLKEGGLIDK
    • Predicted molecular weight

      14 kDa including tags
    • Amino acids

      727 to 837
    • Tags

      His tag N-Terminus
    • Additional sequence information

      GenBank Accession No. NM_021078.2.

Specifications

Our Abpromise guarantee covers the use of ab198113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Additional notes

    ab198113 is useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Store at -80°C. Avoid freeze / thaw cycle.

    pH: 8
    Constituents: 0.63% Tris HCl, 0.64% Sodium chloride, 0.02% Potassium chloride, 0.04% Tween, 20% Glycerol

General Info

  • Alternative names

    • 1110051E14Rik
    • AW212720
    • EC 2.3.1.48
    • GCN 5
    • Gcn5
    • GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2
    • GCN5 general control of amino-acid synthesis 5-like 2 (yeast)
    • GCN5L2
    • general control of amino acid synthesis 5-like 2
    • General control of amino acid synthesis protein 5-like 2
    • General control of amino acid synthesis, yeast, homolog-like 2
    • HGCN5
    • Histone acetyltransferase GCN5
    • Histone acetyltransferase KAT2A
    • hsGCN5
    • K(lysine) acetyltransferase 2A
    • KAT2 A
    • KAT2A
    • KAT2A_HUMAN
    • Lysine acetyltransferase 2A
    • MGC102791
    • PCAF-b
    • STAF97
    see all
  • Function

    Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • Tissue specificity

    Expressed in all tissues tested, with most abundant expression in ovary.
  • Sequence similarities

    Belongs to the GCN5 family.
    Contains 1 bromo domain.
    Contains 1 N-acetyltransferase domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt

Images

  • 4-20% SDS-PAGE analysis of ab198113.

    Lane 1: 2 µg ab198113
    Lane 2: Protein marker

    Stained with Coomassie Blue.

References

ab198113 has not yet been referenced specifically in any publications.

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