The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Histone acetyltransferase binding to hORC1
Histone acetyltransferase binding to ORC1
Histone acetyltransferase KAT7
Histone acetyltransferase MYST2
K(lysine) acetyltransferase 7
Lysine acetyltransferase 7
MOZ YBF2/SAS3 SAS2 and TIP60 protein
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
MYST histone acetyltransferase 2
MYST protein 2
SAS2 and TIP60 protein 2
TIP60 protein 2
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
Ubiquitously expressed, with highest levels in testis.
Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger.
The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.
Phosphorylated upon DNA damage, probably by ATM or ATR.