Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQA LPSVSENSVDDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNEC
    • Amino acids
      1 to 100
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab162322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • A type potassium channel modulatory protein 2
    • A-type potassium channel modulatory protein 2
    • Cardiac voltage gated potassium channel modulatory subunit
    • Cardiac voltage-gated potassium channel modulatory subunit
    • DKFZp566L1246
    • KChIP 2
    • KChIP2
    • KCIP2_HUMAN
    • KCNIP 2
    • Kcnip2
    • Kv channel interacting protein 2
    • Kv channel-interacting protein 2
    • MGC17241
    • Potassium channel interacting protein 2
    • Potassium channel-interacting protein 2
    see all
  • Function
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart.
  • Tissue specificity
    Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
  • Sequence similarities
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Post-translational
    modifications
    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
  • Cellular localization
    Cell membrane and Cell membrane. Detected on lipid rafts (By similarity).
  • Information by UniProt

Images

  • ab162322 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab162322 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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