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    recombinant-human-kcnc3-protein-ab158780.pdf

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Neuroscience Neurotransmission Receptors / Channels Potassium Channels
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Recombinant Human KCNC3 protein (ab158780)

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SDS-PAGE - Recombinant Human KCNC3 protein (ab158780)

    Key features and details

    • Expression system: Wheat germ
    • Tags: GST tag N-Terminus
    • Suitable for: ELISA, WB

    Description

    • Product name

      Recombinant Human KCNC3 protein
    • Expression system

      Wheat germ
    • Protein length

      Protein fragment
    • Animal free

      No
    • Nature

      Recombinant
      • Species

        Human
      • Sequence

        ALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLLTDYAPSPDGS IRKATGAPPLPPQDWRKPGPPSFLPDLNANAAAWISP
      • Amino acids

        671 to 757
      • Tags

        GST tag N-Terminus

    Specifications

    Our Abpromise guarantee covers the use of ab158780 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      ELISA

      Western blot

    • Form

      Liquid
    • Additional notes

       

       

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

      pH: 8.00
      Constituents: 0.31% Glutathione, 0.79% Tris HCl

    General Info

    • Alternative names

      • Kcnc3
      • KCNC3_HUMAN
      • KSHIIID
      • KV3.3
      • Potassium voltage gated channel Shaw related subfamily member 3
      • Potassium voltage gated channel subfamily C member 3
      • Potassium voltage-gated channel subfamily C member 3
      • SCA13
      • Shaw related subfamily, member 3
      • Shaw related voltage gated potassium channel protein 3
      • Spinocerebellar ataxia 13
      • Voltage gated potassium channel protein KV3.3
      • Voltage gated potassium channel subunit Kv3.3
      • Voltage-gated potassium channel subunit Kv3.3
      see all
    • Function

      This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
    • Involvement in disease

      Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13) [MIM:605259]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.
    • Sequence similarities

      Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
    • Domain

      The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
      The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    • Cellular localization

      Membrane.
    • Target information above from: UniProt accession Q14003 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt

    Images

    • SDS-PAGE - Recombinant Human KCNC3 protein (ab158780)
      SDS-PAGE - Recombinant Human KCNC3 protein (ab158780)
      ab158780 on a 12.5% SDS-PAGE stained with Coomassie Blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab158780? Please let us know so that we can cite the reference in this datasheet.

    ab158780 has not yet been referenced specifically in any publications.

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