Overview

  • Product name

    Recombinant Human KDEL Receptor protein
  • Protein length

    Full length protein

Description

  • Nature

    Recombinant
  • Source

    Wheat germ
  • Amino Acid Sequence
    • Species

      Human
    • Sequence

      MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLD LFTNYISLYNTCMKVVYIACSFTTVWLIYSKFKATYDGNHDTFRVEFLVV PTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSKTGEAETITSH YLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYIT KVLKGKKLSLPA
    • Amino acids

      1 to 212
    • Tags

      GST tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form

    Liquid
  • Additional notes

    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names

    • ER lumen protein retaining receptor 1
    • ERD 2
    • ERD2
    • ERD2.1
    • ERD21
    • HDEL
    • KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 1
    • KDEL (Lys-Asp-Glu-Leu) 72 kD endoplasmic reticulum protein retention receptor 1
    • KDEL endoplasmic reticulum protein retention receptor 1
    • KDEL R1
    • KDEL receptor 1
    • KDELR 1
    • KDELR1
    • PM 23
    • PM23
    • Putative MAPK activating protein PM23
    see all
  • Relevance

    Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.
  • Cellular localization

    Endoplasmic reticulum

Images

  • ab153142 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153142 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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