Description

  • Product name

    Recombinant Human KDM3B / JMJD1B protein (Tagged)
  • Purity

    > 90 % SDS-PAGE.

  • Expression system

    Escherichia coli
  • Accession

  • Protein length

    Protein fragment
  • Animal free

    No
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      MPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLI TAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADE VTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPI HDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSC IKVAEDFVSPEHVKHCFRLTQEFR
    • Predicted molecular weight

      46 kDa including tags
    • Amino acids

      1498 to 1721
    • Tags

      His tag N-Terminus
    • Additional sequence information

      JmjC domain with 10xHis-SUMO tag at the N-terminus and a Myc tag at the C-terminus.

Specifications

Our Abpromise guarantee covers the use of ab225962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form

    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Constituents: 50% Glycerol, Tris buffer

General Info

  • Alternative names

    • 5qNCA
    • C5orf7
    • JHDM2B
    • JmjC domain containing histone demethylation protein 2B
    • JmjC domain-containing histone demethylation protein 2B
    • jmjd1b
    • Jumonji domain containing 1B
    • Jumonji domain containing protein 1B
    • Jumonji domain-containing protein 1B
    • KDM3B
    • KDM3B_HUMAN
    • KIAA1082
    • Lysine (K) specific demethylase 3B
    • Lysine-specific demethylase 3B
    • NET22
    • Nuclear protein 5qNCA
    see all
  • Function

    Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
  • Tissue specificity

    Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
  • Sequence similarities

    Belongs to the JHDM2 histone demethylase family.
    Contains 1 JmjC domain.
  • Domain

    Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab225962 has not yet been referenced specifically in any publications.

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