Gene amplified in squamous cell carcinoma 1 protein
JmjC domain containing histone demethylation protein 3C
JmjC domain-containing histone demethylation protein 3C
Jumonji domain containing 2C
Jumonji domain containing protein 2C
Jumonji domain-containing protein 2C
Lysine (K) specific demethylase 4C
Lysine demethylase 4C
Lysine-specific demethylase 4C
Tudor domain containing 14C
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Overexpressed in several esophageal squamous cell carcinomas (ESCs).
SDS-PAGE - Recombinant Human KDM4C / GASC1 / JMJD2C protein (ab167940)
SDS Page analysis of ab167940
This product has been referenced in:
Jin C et al. Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens. Proc Natl Acad Sci U S A111:9235-40 (2014).
Read more (PubMed: 24928520) »